La Roja dropped to second spot in Group 4 of the UEFA Nations League after drawing 1-1 with Switzerland on Saturday night.
Ramos had the chance to get two goals on the night from the penalty spot, but saw both shots saved by Swiss shot-stopper Yann Sommer.
"Sergio Ramos' record with penalties is up there with the very best," Luis Enrique said after the game, as per Goal.
"It would be very unfair to take him off because he's missed one, two, three.
"If there were another penalty, he would've taken it...if he misses two, to take him off penalty duties would be a joke. There's a list of penalty takers and Sergio Ramos is at the top."
Before Saturday's match, Ramos had netted 25 straight penalties for Spain and Real Madrid.
9- Philippe Coutinho (FC Barcelona) – £240 000-a-week
8- Joao Felix (Atletico Madrid) – £256 000-a-week
7- Koke (Atletico Madrid) – £270 000-a-week
6) Sergio Ramos (Real Madrid) – £280 000-a-week
5) Antoine Griezmann (FC Barcelona) – £322 000-a-week
4) Frenkie de Jong (FC Barcelona) – £336 000-a-week
3) Jan Oblak (Atletico Madrid) – £350 000-a-week
2) Eden Hazard (Real Madrid) – £400 000-a-week
1) Lionel Messi (FC Barcelona) – £580 000-a-week