Mamelodi Sundowns find themselves 3-1 down against Borussia Dortmund at halftime.
Coach Miguel Cardoso handed a start to former Dortmund winger Tashreeq Matthews following Wednesday's win over Ulsan HD, with Arthur Sales dropping to the bench
The Brazilians went on to take the early lead when Lucas Costa Ribeiro showed some class by taking the ball in his own half before racing clear and slotting home from close range.
Sundowns' joy was short-lived as Dortmund equalised on 11 minutes when Ronwen Williams gifted the ball straight to Lukas Nmecha, who needed no second invitation to fire into an empty net.
The Bundesliga giants completed the turnaround on 34 minutes when Julian Brandt raced to the byline before picking out Serhou Guirassy, who rose well before heading into the back of the net.
Dortmund were not done there as Jobe Bellingham marked his first start for the club with a goal when he volleyed home from just inside the box after Williams cleared Brandt's cross.
Confirmed line-ups:
Mamelodi Sundowns: Williams, Kekana, Cupido, Mudau, Lunga, Mokoena, Ribeiro, Allende, Matthews, Zwane, Rayners.
Subs: Onyango, Khoza, Lebusa, Modiba, Adams, Sales, Maema, Aubaas, Letlhaku, Mkhulise, Morena, Mdunyelwa, Mvala, Mothiba, Shalulile
Borussia Dortmund: Kobel, Couto, Anton, Sule, Bensebaini, Nmecha, Bellingham, Brandt, Gross, Svensson, Guirassy