The France international will miss this weekend’s visit of Premier League leaders Manchester City to Old Trafford through suspension as he starts a three-match ban for his red card at Arsenal last Saturday.
And Manchester City midfielder Fernandinho feels the Red Devils will have a tough time replacing their record signing, saying: "Of course, any team that loses such a good player, they are going to miss him.
"But Manchester United have good players and it doesn't matter who is going to play in his position, they will do a good job. It will be a tough game for both teams."
City head to the Theatre of Dreams on Sunday holding an eight-point lead the second-placed United, setting up a potentially season-defining encounter in the English top-flight.