Frank Lampard's Chelsea side kick-start this weekend's proceedings with a tricky encounter against Crystal Palace on Saturday while Pep Guardiola's Manchester City are in action later in the day when they take on newly-promoted Leeds United.
Table-topping Leicester City will then look to continue their free-scoring form when they host West Ham United on Sunday, before reigning champions Liverpool travel to Aston Villa looking to maintain their perfect start to the campaign.
Sign up here to start making your predictions!