While many coaches and players will probably say they prepare for it like any other game, there's always something different about Derby week.
Players change hairstyles, some arrive at training earlier than usual, bets are made and others avoid being tackled by the defenders in training.
There's always a funny or interesting story to tell about Derby week, so snl24.com/kickoff has tracked down a few former players from both Orlando Pirates and Kaizer Chiefs.
Ex-Chiefs defender Mark Tovey says he adopted a war-like mentality for the Derby.
"In the dressing room ... it [muthi] would start the night before," says 63-year-old Tovey, who played for Amakhosi from 1988 to 1991 and is the older brother of Glamour Boys legend Neil.
"Even at the hotel when we were camping waiting for the meals. We went for meals at Kaizer's [Motaung] house ... it would start there, a night before and in the next day as well, and before lunch. You know I was blessed to be allowed to play for Kaizer Chiefs and I was always first in the queue, always, always first in the queue because I need to make sure the other players can see I'm with them. For sure I was serious all the time, always.
"When it came to Derby day ... no friends from Pirates, because it was war. I don't want to know them, they were the enemy. They won't come past me, Basil Steenkamp won't come past me.
"I think the referees those days, I think there was pressure because it's always a big day and obviously you know you are having a hundred people watching. So there was lot of pressure for the referees but there was no incident that needed to be looked at afterwards."
Asked about his thoughts on Amakhosi coach Giovanni Solinas, Tovey says: "Ja again, I don't know him so much. I don't know his pedigree. I don't think the coaches nowadays have the same management skills as they did in our days you know. I think they complicate the game sometimes too much. You know it's a simple game just complicated by people sometimes. But ja, let's hope the gold and black rise to the occasion. God bless."