Buoyed by Gavin Hunt's first win in charge in the MTN8 last weekend, Chiefs go into the clash with defending champions in high spirits and out for revenge after what happened last season.
The Brazilians are still reeling from being knocked out of the MTN8, with coaching triumvirate Manqoba Mngqithi, Rhulani Mokwena and Steve Komphela going in search of a big first win for the new regime.
Saturday's biggest showdown kicks off at 15h30.
The other big game on Saturday pits AmaZulu against Orlando Pirates, who could see two of their former players lined up against them in Luvuyo Memela and Augustine Mulenga.
Chiefs legend Siphiwe Tshabalala has also joined Usuthu's ranks and headlines a raft of new signings under new owner Sandile Zungu.
On Pirates' side, new signings Richard Ofori and Thabang Monare will be hoping to make their debuts for the Buccaneers.
Then on Sunday three newcomers take the Premiership stage as Swallows FC, TS Galaxy and Tshakhuma FC make their top-flight bows.
Kaizer Chiefs vs Mamelodi Sundowns
Baroka vs Maritzburg United
Bloemfontein Celtic vs Golden Arrows
Cape Town City vs Chippa United
AmaZulu vs Orlando Pirates
SuperSport United vs Black Leopards
Stellenbosch vs Swallows FC
Tshakhuma FC vs TS Galaxy