Usuthu - seen as tournament dark horses - were drawn against Kaizer Chiefs in a two-legged tie.
While Mamelodi Sundowns face Orlando Pirates in the alternate fixture.
The last time the KwaZulu-Natal outfit lifted silverware was 30 years ago when beating a star-studded Amakhosi side 3-1 in a Coca-Cola Cup final.
"We were expecting anyone because our goal is to go to the final and win the cup," Ntuli tells KickOff.
"It didn't matter whether we drew Kaizer Chiefs or Sundowns or Pirates.
"Because we expect everyone that is in the semi-final to be tough, you can't expect a team that has reached a semi-final to take their foot off the pedal.
"Kaizer Chiefs are a big team and we respect them, but we are also planning to win.
"We never even thought or talked about who would we prefer to face in the semi-finals because we were well aware all the other three teams are big.
"We are expecting a tough match against Chiefs, it's a game we should never take lightly.
"It's good that we will be playing home and away because we know we also have supporters that will give us that push.
"We want to win this cup, we know we are not favourites, but we will surprise them, and we believe we will win it."