Pyramids FC started their Group A campaign on a winning note after thumping ten-man Enugu Rangers at Nnamdi Azikwe Stadium.
Ibrahim Olawoyin opened the scoring for Rangers in the 28th minute but the Nigerian side were down to ten men in first-half stoppage time after Tope Olusesi got his second booking.
The Egypyian outfit came back in the second stanza as Mohamed Farouk levelled matters nine minutes after the break, while Amor Layouni and Islam Issa netted two late goals to seal the three points.
Libya's Al-Nasr and Djoliba AC of Mali opened their Group C campaign with a 1-1 draw at 28 March Stadium.
Abdourahamane Bah broke the deadlock for the visitors seven minutes after the break but Khalid Almaryami salvaged a point for the Libyan side with the equaliser in the 68th minute from the penalty spot.
Ten-man Zanaco were held to a 1-1 draw by Motema Pembe in their Group B opener at Stade des Martyrs.
Mousa Souleymanou opened the scoring for Zanaco in the 25th minute but the Zambian side were reduced to ten men in the 66th minute after Kelvin Kapumbu got a second yellow card.
Peter Kolawole got the equaliser for Motema with 12 minutes remaining to salvage the share of the spoils.
Morocco's RSB Berkane had a dream start in Group B after easing to a 3-0 victory over FC Esae of Benin at Stade Municipal de Berkane.
Zaid Krouch and Hamdi Laachir gave Berkane a two-goal cushion going to the break before Djibril Ouatara sealed the three points with the third goal four minutes before time.
Ivorian side San Pedro and Paradou of Algeria opened their Group D campaign with a goalless draw at Stade Auguste Denise.
Nigerian giants Enyimba opened their Group D campaign on the back-foot after going down 2-0 to Hassania Agadir of Morocco at Stade Adrar.
First-half goals from Malick Cisse and Karim El Berkaoui were enough to hand Hassania three points that took them to the top of the pool.
Al Masry of Egypt were on the winning side of a 3-2 score-line against Nouadhibou of Mauritania in a five-goal thriller in a Group A at Stade Municipal de Nouadhibou.
Austin Amutu scored a vital brace for the Egypian side but Kareem El Iraky netted a stoppage time winner, after Boubacar Bagili and Cheick Elwely had levelled up for Nouadhibou.