Djoliba thrashed Elect-Sport 4-0 in Bamako in the second leg of the play-off round.
After the first leg ended 1-0, Almamy Camara, Salif Coulibaly, Anthony Bah and David Ekwa compelled the visitors misery on Sunday evening.
San Pedro overturned a 1-0 first-leg deficit to overcome a ten-man Asante Kotoko 2-0 in Abidjan.
The Ivorians made a swift start through Cheick Soumaro before Amede Diomande netted the second goal in the final minute of the match that his side through to group stages.
Hassania Agadir fought off a resilient Green Eagles to stage a come from behind 2-1 victory in their second-leg clash in Agadir.
Tapson Kaseba had Eagles in front on 56 minutes following a goalless first half, but Ayoub El Mallouki responded on 70 minutes before Karim El Berkaoui completed the turnaround three minutes to go.
RSB Berkane showed no mercy to Fosa Juniors after romping to a 5-0 humiliation at the Stade Municipal de Berkane.
Adama Traore and Mohamed Aziz bagged braces, while Hamdi Laachir rounded off the scoring in the second half
Pyramids cruised comfortably to the group phases following a 3-0 victory over Young Africans on Sunday.
Eric Traore, Mohamed Farouk and Abdallah El Said secured the goals for the Egyptian Premier League outfit.
Paradou clinched the final group stage spot with a 4-1 aggregate victory over Kampala City Council Authority FC at home.
Hairan, Yousri Bouzok, Abdelkahar Kadri and Aimen Bouguerra were on target for the home side, while Allan Okello netted a consolation for the visitors.