Sundowns have qualified for the quarter-finals as the winners of Group B, where they have accumulated 12 points from four games and have won all their games against TP Mazembe, Al Hilal and CR Belouizdad, who are all winless in the group.
The Brazilians are now guaranteed to finish in top spot in the group and could face reigning champions Al Ahly, who are still three points behind Simba SC in Group A, in the knockout stage.
The prospect of Mosimane coming up against his former team and understudy has Mngqithi sober in his thoughts and approach, insisting he will not take personal emotions into the encounter.
"Facing Pitso, or facing any other coach, for me it should never be an emotional game. I always look at the game and the opponents," said the Sundowns co-coach in a virtual press conference.
"I'm working with monsters here who do a lot of good work behind the scenes to make sure that we know [everything] about any opponent we are playing against.
"The most important thing is to get to the quarter-final, because this thing of avoiding big boys and all that also has a lot of dynamics.
"If we happen to play against Al Ahly, we wouldn't have avoided a big boy then, so to be honest there's no avoiding anyone.
"Once you get into the last eight of the Champions League, you are most likely to face teams that have won the competition – if you avoid Al Ahly, you might find Esperance; if you don't find Esperance, you'll find Wydad... But you are always likely to face one of the big six teams."