Holders Real remain in contention for a record-breaking three consecutive Champions League titles, but face a mammoth task to reach the semi-finals after drawing Serie A leaders Juventus - a repeat of last seasons final.
FC Barcelona were rewarded for their impressive Last 16 victory over Premier League giants Chelsea with a mouthwatering fixture against Italian outfit AS Roma.
Bundesliga giants Bayern Munich were drawn against surprise package Sevilla, who dumped Manchester United out of the competition with a spectacular second-leg victory at Old Trafford in the previous round.
In the fourth and final fixture, Liverpool come up against Manchester City in an all-English encounter for a place in the last-four of Europe's elite club competition.
Roma vs Barcelona
Sevilla vs Bayern Munich
Liverpool vs Manchester City
Real Madrid vs Juventus