Ronaldo is reportedly eager to leave Old Trafford for the upcoming season after the club missed out on the UEFA Champions League spots last campaign.
The likes of Bayern Munich and Chelsea have already decided against signing the five-time Ballon d'Or winner despite both clubs losing big-name strikers.
There have been reports that Atletico could be interested in signing the former Real Madrid star, although they would need to offload a couple players first.
However, Koke says there has been no discussion about their former rival in the dressing room leading up to the new season.
"There is no talk of Cristiano Ronaldo in the dressing room. My teammates are great players," Koke told Director Gol.
"We have strikers from Argentina, Brazil, some from Portugal, France and Spain.
"Great players who can do great things. I trust them all."