Mohamed Salah made his 150th Premier League start for Liverpool, who had James Milner as captain whereas Arsenal featured Martin Odegaard and Thomas Partey in the midfield.
A quiet start marred the opening exchanges despite a succession of half-hearted attempts at either end from first Alexandre Lacazette on the side of Arsenal followed by Sadio Mane for the Reds.
Liverpool carved the first decent opening 15 minutes in when a loose clearance from a cross by Andrew Robertson fell to Fabinho, who flashed narrowly past the far post from 30 yards out.
It seemed to open up more for the Reds 15 minutes later as Roberto Firmino created space in the area to drill a clear strike from a decent position agonizingly wide of the mark.
The Gunners' approach was thrown into jeopardy on the brink of halftime, as Cedric Soares came on to replace Kieran Tierney who couldn't carry on playing due to injury.
Liverpool maintained advantage moments following the start of the second half with Salah closing in with a smart attempt from afar, but the opposing defence parried the Egyptian.
Mikel Arteta's men finally cracked midway through the second stanza after Diogo Jota got on the end of a telling cross from Alexander-Arnold to nod home despite the best efforts of Bernd Leno.
Within the last 20 minutes, it was two after Salah ghosted in from the inside-right of the area to slip a loose clearance in the area from Gabriel Magalhaes past Leno.
Arsenal were caught out with eight minutes to go as a misplaced pass from the back was seized upon by Mane who delivered cross-field for Jota to tap home his brace.
The victory elevates the Reds from seventh to fifth spot on the league standings, with the Gunners heading back to the drawing board.
