All four quarter-finals will be played on the weekend of 14 and 15 August 2021. Defending champions, Orlando Pirates, will get proceedings under way when they host Swallows FC at the Orlando Stadium on Saturday, 14 August 2021.
Kick-off is scheduled for 15:00. Later on Saturday, Lamontville Golden Arrows and SuperSport United will square off at the Princess Magogo Stadium in KwaZulu-Natal.
Kick-off is at 18h00.
On Sunday afternoon, Mamelodi Sundowns and Kaizer Chiefs will lock horns at the Lucas Moripe Stadium in Atteridgeville.
Kick-off is at 15:00.
Then later in the evening at 18:00, AmaZulu FC will enjoy home ground advantage when they welcome Cape Town City to the Moses Mabhida Stadium.
2018: SuperSport United 1(1) - 1(4) Cape Town City (penalties)
2017: SuperSport United 1(4) - 1(2) Cape Town City (penalties)
2016: Bidvest Wits 3-0 Mamelodi Sundowns
2015: Ajax Cape Town 1-0 Kaizer Chiefs
2014: Kaizer Chiefs 1-0 Orlando Pirates
2013: Platinum Stars 1(3) - 1(1) Orlando Pirates (penalties)
2012: Moroka Swallows 2-1 SuperSport United
2011: Orlando Pirates 1-0 Kaizer Chiefs
2019: SuperSport United 1-0 Highlands Park
2020: Orlando Pirates 2-1 Bloemfontein Celtic