Pitso Mosimane's Al Ahly started the new year with a goalless draw against Wadi Degla on Friday night.
Mosimane returned to the bench in Monday's big win over Al Ittihad after recovering from the coronavirus.
Ahmed Mohamed, Walid Soliman, Hussein El Shahat and Salah Mohsen were back in the line-up for the Red Devils, who were looking to claim a fourth straight league win.
It wasn't smooth sailing for Mosimane's charges early on as Al Ahly goalkeeper Mohamed El Shanawy was called upon to keep out Diego Calderon just before the 20-minute mark.
After a slow start to the encounter, the Red Devils went close with their first meaningful opening in the 35th minute after Soliman fired one over the target.
Another chance fell the way of the defending league champions on the stroke of halftime, but Mohsen was unable to guide his header on target as the frustration began to grow.
Al Ahly carried that momentum into the second half, with Ali Maaloul seeing his powerful effort turned away by Wadi Degla shot-stopper Mohamed Abdel-Monsef.
Abdel-Monsef continued frustrate Mosimane's men after producing another good save, this time to keep out Bard Banoun volley in the final 17 minutes.
There was a chance for a late winner for Al Ahly but Ahmed Yesser sent his header over Abdel-Monsef's crossbar, as the Red Devils drop their first points of the season.
Scroll through the gallery below to see Al Ahly's Egypt Cup celebrations: