Bayern will be determined to avoid complacency with their slender 2-1 advantage, having witnessed FC Barcelona suffered a shock exit last night.
The Bundesliga champions secured two away goals in Spain last week but they will remain wary after the LaLiga outfit dumped Manchester United out in the last-16 at Old Trafford.
In only the second time the sides meet in European competitions, the visitors don't boast much experience, having never reached the semi-final of Europe's elite club competition.
Robert Lewandowski will be the key man for the home side, having netted six goals in his last seven Champions League knock-out fixtures, while Wissam Ben Yedder has scored 10 in as many games for Los Rojiblancos.
Here is how both teams will line up:
FC Bayern: Ulreich; Rafinha, Hummels, Boateng, Kimmich, Martinez, James, Muller, James, Robben, Ribery, Lewandowski.
Sevilla: Soria; Lenglet, Mercado, Escudero, Navas, N'Zonzi, Banega, Correa, Sarabia, Ben Yedder, Vazquez.