The France and Tottenham goalkeeper who his country to World Cup glory earlier this summer, was stopped by police in his car in central London at around 2.20am.
He failed a roadside breathalyser test and was taken to Charing Cross Police Station, where he spent around seven hours in custody before being charged and released on bail.
The 31-year-old has been ordered to appear at Westminster magistrates court on September 11.
"A man has been charged following a routine patrol stop in Gloucester Place, W1. Hugo Lloris, 31, of East Finchley, was charged with drink driving on Friday, 24 August," The Metropolitan Police said.
"He has been bailed to return to Westminster Magistrates' Court on Tuesday, 11 September."
Lloris is now a major doubt to feature for Spurs ahead of their crucial Premier League encounter against Manchester United this weekend.