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Manchester United kick the gameweek off with an afternoon trip to Brighton & Hove Albion on Saturday and Ole Gunnar Solskjaer's charges will be looking to bounce back following their shock 3-1 defeat to Crystal Palace last weekend.
Early pace-setters Leicester City are then hosted by Pep Guardiola's title contenders Manchester City on Sunday before reigning champions Liverpool seek to get revenge over Arsenal on Monday after their Community Shield defeat earlier in the campaign.
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Check out the full list of opening fixtures below:
Saturday 26 September
- Brighton & Hove Albion vs Manchester United
- Crystal Palace vs Everton
- West Bromwich Albion vs Chelsea
- Burnley vs Southampton
Sunday 27 September
- Sheffield United vs Leeds United
- Tottenham Hotspur vs Newcastle United
- Manchester City vs Leicester City
- West Ham United vs Wolverhampton Wanderers
Monday 28 September
- Fulham vs Aston Villa
- Liverpool vs Arsenal