Reigning champions Liverpool will look to bounce back from their 7-2 defeat to Aston Villa when they meet rivals Everton on Saturday. Make your predictions on this and other Premier League matches to stand a chance of winning cash prizes!
The action kicks off with a mouthwatering Merseyside derby between Jurgen Klopp's Reds and Carlo Ancelotti's Toffees on Saturday afternoon, before old allies Pep Guardiola and Mikel Arteta are reunited when Manchester City play host to Arsenal.
Tottenham Hotspur's clash against West Ham United is arguably the pick of Sunday's fixtures, and is followed by an all-action encounter between the high-flying pair of Leicester City and Aston Villa.
The weekend's fixtures spill over to Monday evening when West Bromwich Albion host Burnley, before the free-flowing football of Wolverhampton Wanderers will be tested against Marcelo Bielsa's tactical and energetic Leeds United.
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Check out the full list of opening fixtures below:
Saturday, 17 October
- Everton vs Liverpool
- Chelsea vs Southampton
- Manchester City vs Arsenal
- Newcastle United vs Manchester United
Sunday, 18 October
- Sheffield United vs Fulham
- Crystal Palace vs Brighton & Hove Albion
- Tottenham Hotspur vs West Ham United
- Leicester City vs Aston Villa
Monday, 19 October
- West Bromwich Albion vs Burnley
- Leeds United vs Wolverhampton Wanderers