Orlando Pirates will be looking to exact revenge on home soil when they host Ajax Cape Town in the last-32 of the Nedbank Cup on Saturday, having lost 3-0 to the relegation-threatened Urban Warriors in the league a week ago.
Also tomorrow, Tottenham entertain fierce rivals Arsenal in the Premier League as both sides chase a top-four finish in the wake of runaway leaders Manchester City, who are set to host mid-table Leicester City.
The next day Manchester United and Liverpool will aim to keep the pressure on Pep Guardiola's side when they make intriguing trips to lowly Newcastle United and Southampton respectively.
Closer to home, Kaizer Chiefs will start their Nedbank Cup campaign against misfiring Durban-based outfit Golden Arrows at FNB Stadium.
La Liga giants Barcelona and Real Madrid are likewise in action this weekend, along with Bundesliga table-toppers Bayern Munich.
KickOff Predictor - Round 67 fixtures:
Saturday 10 February
Orlando Pirates v Ajax CT
Tottenham v Arsenal
Man City v Leicester
Bayern Munich v Schalke
Real Madrid v Real Sociedad
Sunday 11 February
Kaizer Chiefs v Golden Arrows
Newcastle v Man United
Southampton v Liverpool
Nantes v Lille
Barcelona v Getafe