Reigning PSL champions Bidvest Wits take on Bloemfontein Celtic for the second available piece of silverware in South Africa as the Princess Magogo Stadium plays host to the TKO showpiece.
Then, in the Premier League, the Emirates Stadium sets the scene as fierce rivals Arsenal and Manchester United lock horns for three priceless points in the race for title glory on Saturday evening.
Elsewhere, La Liga action returns to Spain where Barcelona and Real Madrid are in action against Celta Vigo and Athletic Bilbao respectively.
On Sunday, runaway Premier League leaders Manchester City will be looking to make it 15 matches without defeat as they host West Ham, while Bournemouth are in action at home against Southampton.
KickOff Predictor - Round 57 fixtures:
Saturday 2 December
Arsenal v Manchester United 19:30
Chelsea v Newcastle United 14:30
Brighton v Liverpool 17:00
Bidvest Wits v Bloemfontein Celtic 18:00
Barcelona v Celta Vigo 14:00
Athletic Bilbao v Real Madrid 21:45
Sunday 3 December
Bournemouth v Southampton 15:30
Manchester City v West Ham 18:00
Saint Etienne v Nantes 16:00
Inter Milan v Chievo 16:00