It was another disappointing night at the Emirates Stadium for Arsenal, who suffered a 2-1 loss to Wolverhampton Wanderers.
David Luiz and Bukayo Saka were recalled to the Premier League, with Rob Holding dropping to the bench while Nicolas Pepe was suspended.
The visitors were forced into a re-shuffle after just five minutes as nasty clash of heads between Raul Jimenez and Luiz saw the Wolves striker stretchered off and taken straight to hospital.
Even after losing their star striker, Wolves got the opening goal in the through Neto's close-range finish after Leander Dendoncker saw his initial header crash against the woodwork.
The Gunners hit back straight away as defender Gabriel Magalhaes rose above his marker to head home Willian's corner for his second league goal.
However, Wolves restored their lead just before the halftime break when Daniel Podence reacted quickest to Bernd Leno's save to fire into an empty net.
After a strapped-up Luiz was replaced at halftime, the Gunners threw everything forward in search of an equaliser as Saka and Holding squandered good chances in the opening 15 minutes of the second stanza.
Pierre-Emerick Aubameyang had the chance to end his poor run in front of goal from open play on 81 minutes, but the Gunners striker headed wide of the target from Hector Bellerin's cross.
In the end, Aubameyang's miss prove costly as Wolves held on to claim a win, while Mikel Arteta's side suffer a third successive loss in the league on home soil.