Stuart Baxter selected a much-changed squad for last week’s first-leg clash in Sudan, which Matsatsantsa narrowly lost 3-2, meaning they need a 1-0 victory in Tshwane this weekend to progress to the next stage of the competition.
And former University of Pretoria star Mnyamane is counting on home comforts to help them achieve their target, given the soaring temperatures they played under in Sudan.
"It's our home game and I believe we are going to win because conditions that side were not conducive [to playing football],” said Mnyamane, whose club are yet to reach the group stages of this tournament.
"We drove four hours to the stadium [from the airport in Sudan] before we played. Our hotel was not good so it was a bit of a hustle but it's no excuse that we lost, but we should've won.
"But coming to our home game, obviously we are going to win and give our own account.
"I also want experience by playing in Africa and for me it is always the shirt for the team that we've to fight for in Africa."
Mnyamane has enjoyed a rich vein of form in his first season with Baxter’s team, bagging seven goals and as many assists in all competitions, which have helped lead to his recent call-up to the Bafana Bafana squad.
However, Mnyamane - who was again on target in the 2-1 Nedbank Cup last-32 win over Royal Eagles on Wednesday - insists his recent good form is a result of the whole team playing well.
"It is just that the team is doing well and when we do well obviously things are going to flow for players, so the team is doing well," said Mnyamane, who will be hoping to feature for Bafana when they face Guinea-Bissau and Angola in friendly internationals on March 25 and 28.
He added: "I get the confidence from the team, from team-mates, from supporters, and I'm trying to always to put in a good shift for the team and that comes with goals, I guess.
"I think I also adapted at the club during pre-season. When I came in it took a couple of days to adapt. And the coach told me that he believes in me and he gave me the confidence. He showed me one or two things and my team-mates as well and I know some of the players, so it was easy for me to adapt.”