From the team that lost 1-0 to Bloemfontein Celtic in their last outing, Siyabonga Mpontshane, Ayanda Gcaba, Mpho Makola, Rooi Mahamutsa, Tendai Ndoro and Kermit Erasmus miss out.
In comes Felipe Ovono, Thabo Matlaba, Patrick Phungwayo, Thandani Ntshumayelo, Thamsanqa Gabuza and Sifiso Myeni.
A win for Pirates will see them top the group and face Tunisian side Etoile du Sahel in the semifinals, while a draw or defeat will see them up against Al-Ahly.
The referee for tonight’s game is Hudu Munyemana from Rwanda.
Pirates: Ovono, Matlaba, Sangweni, Jele, Phungwayo, Rakhale, Ntshumayelo, Sarr, Myeni, Manyisa, Gabuza
Subs: Mahamutsa, Nyauza, Masalesa, Makola, Erasmus, Majoro, Masuku