CAF, the continental football governing body, decided the preliminary round match-ups via a draw held today in Cairo.
Pirates automatically advance to the next stage of the competition where they will meet either Elgeco Plus of Madagascar or Uganda Revenue Authority.
ASEC Mimosas, Zamalek, Djoliba, F.U.S, AS Vita, Ahli Shendi, Club Africain and ESS are also already through to the first round.
The first leg is scheduled for 13, 14, 15 February, with the return match on 27, 28 February and 01 March.
Bidvest Wits vs Royal Leopards (SWA)
Young Africans vs BDF XI (BOT)
Benfica de Luanda vs Messager Ngozi (BUR)
Volcan Club de Moroni (COM) vs Atletico Petroleos (ANG)
Petite Riviere Noire (MRI) vs Ferroviario da Beira (MOZ)
MC Alger vs Sahel SC (NIG)
RSB (MOR) vs Onze Createurs (MLI)
Al Ittihad (LBY) vs Elect Sport (CHA)
Ghazala (SSD) vs Petrojet
Unisport du Haut Nkam (CMR) vs Olympique de Ngor (SEN)
Hearts of Oak vs AS Police (BEN)
ASO Chlef vs Kamboi Eagles (SLE)
Horoya AC vs Fassel (LBR)
Leones Vegetarianos (EQG) v Dolphins (NGA)
Cote d'Or (SEY) vs Dedebit
RCB (BFA) vs Warri Wolves
Etoile du Congo (CGO) vs FC MK (DRC)
Panthere du NDE (CMR) vs Rayon Sports (RWA)
AS Togo Port de Lome (TOG) vs CARA (CGO)
Khartoum (SUD) vs Power Dynamos
CF Mounana (GAB) vs Polisi (ZAN)
URA (UGA) vs Elgeco Plus (MAD)
Sofapaka vs Platinum (ZIM)