Wits coach Gavin Hunt has decided to rest the pair with an eye to Tuesday's crucial League match against title rivals Mamelodi Sundowns at Bidvest Stadium.
Winger Sameehg Doutie and veteran striker Henrico Botes also did not make the trip to Lobamba.
“We do respect Leopards, but we are definitely going to take the game to them. I can’t predict the score but we will be going all out," said Hunt ahead of the 17h00 kick-off.
The Clever Boys enjoy a 3-0 lead from the first leg played in Johannesburg a fortnight ago.