Downs on Friday jet off for the first leg tie in Kinshasa, which will start at 16h30 at Stade Tata-Raphael on Sunday.
Mosimane is without key attacker Khama Billiat and defender Soumahoro Bangaly through suspension, but Absa Premiership Player of the Month Hlompho Kekana returns to bolster the engine room.
"Fortunately Kekana will be back," says Mosimane, who on Wednesday was named Absa Premiership Manager of the Month for January and February.
"We don't have Billiat and Bangaly. We have to make a plan in the midfield. We need to have the midfield very tight and not allow anything there."
Mosimane is desperate for his side to score an away goal.
"A result to get there is 1-1. It's a very good result. It's a draw but it is good, we scored away. Nil-nil is not as good as 1-1. You need to score (away) and then you have a chance here.
"The manner in which we played our last games here in Atteridgeville, we are showing good signs. We showing that we can score."
'Jingles' has been keeping tabs on their upcoming opponents.
"If the team from Mozambique managed to lose 1-0 in Kinshasa in the 84th minute through a penalty and played a 1-1 in Mozambique, it means that if we get decent results over there we can do something here."