While coach Pitso Mosimane will expect to advance to the next stage, he will know that either of those sides have within them the ability to make life difficult for the 2016 winners.
Sundowns will not participate in the preliminary round that starts in February having been given a bye.
But South Africa’s second entrant, Bidvest Wits, must start at that stage and take on Reunion islands side AS Saint Louisianne, with their second leg at home.
After that they have Egyptian giants Al Ahly waiting in the first round proper, which has the potential to be a hugely intriguing match-up.
South Africa will also have two entrants in the CAF Confederation Cup in 2017.
Nedbank Cup champions SuperSport United will face Madagascan club Elgeco Plus in the preliminary round. If they advance they will play Al Ahly Shandy from Sudan in the first round proper.
Platinum Stars, who finished third in the Absa Premiership in the 2015/16 season, take on Uniao do Songo from Mozambique in their preliminary round tie and are at home first. If Stars advance they will play the winner of the fixture between Vipers SC of Uganda and Volcan de Moroni from the Comoros.
The preliminary round ties in the Champions League and Confederation Cup will be played on the weekends of February 10-12 and 17-19.