Mosimane made the point after Sundowns beat Ghanaian side Medeama SC 3-1 in the first leg of a CAF Confederation Cup play-off tie at Lucas Moripe Stadium on the weekend.
The Absa Premiership and Telkom Knockout champions dropped to the second-tier event after getting knocked out of the CAF Champions League by AS Vita just before the group stages in April.
'Jingles' is well aware a strong run in Africa takes its toll, as has been the case with Orlando Pirates, who have not had a break in the past two seasons.
“It's either we change the programme to suit Africa or we change the programme to suit our local football, you know what I'm trying to say,” Mosimane said.
“I'm the last one to talk about that programme. I have complained a lot about playing every three days. I have complained a lot about playing Orlando Pirates in the Nedbank Cup after AS Vita.
“I complained a lot having to play Vita away and having a big game three days before.”
Downs will revive hostilities with Medeama next week Wednesday, and will return home the day before their final league game of the season against Platinum Stars on May 21.
“We are playing on a Wednesday against Medeama, our game against Platinum Stars is on Saturday and there is no flight that comes out at that time because we are not playing in Accra,” Mosimane continued.
“If we were playing in Accra maybe we can get a flight. We are playing far away, three hours' drive from Accra and we won't get a flight.
“So it means we will travel on Thursday and you arrive on Friday and we play Saturday against Platinum Stars, I mean really guys.
“But I don't want to complain, I just want to keep quiet because we have achieved two cups with the same programme and the last thing is to complain.”