Rashford, 20, performed admirably on international duty with two goals in as many games against Spain and Switzerland which promoted Alan Shearer and Jamie Carragher to question his future at United.
The Premier League legends claimed his development under Mourinho will be stifled due to the lack of game time afforded to him in his favoured central striking role.
However, Mourinho has sensationally hit back at the duo in United's press conference ahead of their away trip to Watford.
"I can expect that Sunday I'm going to be highly criticised for not playing him on Saturday because some of the boys are really obsessed with me and some of them I think a problem with some compulsive lies," he said.
"I can expect that Sunday some of them will wake up in the morning and as always the first thing they think is Jose Mourinho.
"I can imagine on Sunday I am going to be criticised for not playing Marcus, but it is not my fault, he’s suspended, so probably you should remind them that he is suspended and cannot play.”
He went on to detail the precise number of minutes Rashford has played since he took charge at United in 2016 - adding that certain pundits have separate agendas.
"On the season 16-17 Marcus Rashford played 32 Premier League matches, 11 Europa League matches, including the final, three FA Cup matches, six League Cup matches including the final and the Community Shield,” he said.
"He had 53 appearances, but if you want to take to the minutes of play, he played 3068.
"In 17-18, he played 35 Premier League matches, eight in Champions League, five in FA Cup including the final, three League Cup matches and the European Super Cup final. He played a total of 52 matches with 2,676 minutes.
"In two seasons, he had 105 appearances, 5744 minutes, 63.7 matches of 90 minutes, including five finals.
"So the people that is speaking about these minutes, I think they are a bit confused, Marcus Rashford is not Dominic Solanke, not Ruben Loftus Cheek, not Dominic Calvert Lewin, he is Marcus Rashford, Manchester United player, with an incredible number of appearances and an incredible number of minutes played at the highest level in the best possible competitions.
"Since I was here, he was never one day out of selection because of my decision. Only if injured or suspended, he was never ever out of a selection."
Jose Mourinho has an very Jose Mourinho answer for his Rashford critics pic.twitter.com/Kan92XDSt0— Football Daily (@footballdaily) September 14, 2018