Nigeria have already claimed Group B honours and a ticket to Russia 2018 with 13 points. Chipolopolo have seven points, one more than the Indomitable Lions, while Algeria are bottom with a point from five games.
The hosts are without injured right-back Simon Silwimba and midfielder Kondwani Mtonga, but RB Salzburg striker Patson Daka is back following a spell on the sidelines.
Mweene feels it is important to end their campaign on a positive note at Levy Mwanawasa Stadium in Ndola.
"There are disappointments in life but if it wasn’t meant to be, it is not meant to be. As professional footballers, we will have a lot of disappointment but we have to forge ahead because that is not the only game,” Mweene told CAF's website.
“If we continue dwelling on that game we won’t come out of our shell and will always be disappointed.
“What is important is to look forward to this game on Saturday bearing in mind that it may not be important but as a player it is important to finish on a good note.
“It will be encouraging and it will bring positive energy as well considering the team is composed of young players who were playing in their first qualifiers and will be motivated to work extra hard.
“It will be encouraging not only for the younger guys but for us seniors too. We have to show we respect our flag and nation.”
He added: “Games like these give an opportunity for the local guys even if they don’t participate on Saturday. It gives them a chance to show what they can do before they go to camp for the CHAN in December.
“We also have to carry on and improve in the Total AFCON Cameroon 2019 qualifiers. We have Namibia, Mozambique and Guinea Bissau to play and we are on zero points.
“But anything is possible. I have no doubt that with the team that we have we will qualify for Total AFCON Cameroon 2019.”