Modise, who plays her club football for Sasol League outfit Croesus, scored her treble after the break, with Shiwe Nongwanya getting the opener for Vera Pauw's side.
This was the fifth match Banyana have played as part of their preparations for the African Women’s Championships that will be hosted by Namibia from 11-25 October.
The home side enjoyed most of the possession in the opening 10 minutes of the match, putting Banyana under pressure and forcing them to play in their own half.
Goalkeeper Roxanne Barker made a great save by tipping the ball over in the fifth minute, denying She-polopolo a chance to open the scoring.
In the 22nd minute, Banyana came close to breaking the deadlock after Simphiwe Dludlu made a cross into the box, but it fell into the Zambian keeper’s hands
Banyana opened the scoring on the half-hour mark after Nongwanya received a great pass from Refiloe Jane, beating the defenders and scoring from inside the box.
Pauw made her first substitution of the match at the start of the second half, replacing youngster Thembi Kgatlane with Silindile Ngubane.
Banyana changed the pace of the game in the second stanza, enjoying most of the ball possession.
Modise doubled the score for Banyana in the 63rd minute after receiving a hard and low cross from Nongwanya, finishing with an easy tap-in.
Pauw’s charges took control of the match, with Modise adding further goals in the 73rd and 90th minute.
Banyana travel back to South Africa on Monday afternoon to continue with their camp ahead of their next assignment in Polokwane against Tanzania on 31 August.