Kaizer Chiefs and Orlando Pirates, who face SuperSport United and AmaZulu respectively, will both be in Durban for their matches.
The action kicks off with Baroka hosting Mamelodi Sundowns at the New Peter Mokaba Stadium on Saturday, with kick-off set for 15h30.
This will be followed promptly by Usuthu's hosting of The Buccaneers at the earlier confirmed Moses Mabhida Stadium at 18h00.
Usuthu has three home grounds, King Zwelithini Stadium, Princess Magogo Stadium and Moses Mabhida Stadium, by order of preference.— AmaZulu FC (@AmaZuluFootball) October 29, 2018
Telkom has requested a bigger venue which has a spacious precinct that would allow them better brand activation for their Summer of More campaign.
The later kick-off at 20h15 will see Maritzburg United welcome defending champions Bidvest Wits to the Harry Gwala Stadium.
The semi-finalists will then all be decided once Amakhosi have battled it out with Matsatsantsa at the Moses Mabhida Stadium on Sunday afternoon (15h30).
However, despite the PSL's Disciplinary Committee's earlier ruling that handed Chiefs a two-match stadium ban following the crowd violence in the Nedbank Cup fixture in April, this match does not apply.
After serving the first of their two-match stadium ban against Polokwane City on October 6, The Glamour Boys will still have to host Chippa United at the same venue on November 10 without the presence of their supporters.
The reason for the relocation in the first place is due to FNB Stadium's hosting of the annual Soweto Marathon on Sunday.