Josephs, who is closing in on 500 PSL starts since making his Cape Town Spurs debut against African Wanderers in 1997, was notably absent from training on Tuesday at People's Park just outside Moses Mabhida Stadium.
The 38-year-old has not played in the last four matches for the club, with his previous appearance coming against Kaizer Chiefs at FNB Stadium on September 22.
Siyabonga Mbatha, who was at fault for the first goal in the club's 3-0 league loss to Cape Town City last weekend, will continue to be in goals against on-form Orlando Pirates in the Telkom Knockout quarter-finals.
"Moeneeb's mother, she's okay and we are happy for that," said coach Cavin Johnson ahead of Saturday's game with Pirates at Moses Mabhida (18h00).
"He hasn't come back because, like I said before, when things like that happen to my players or things like that happen to my staff, you can go home for three months, six months, it doesn't bother me.
"As long as when you come back all those things are sorted. So he's okay, but he won't be in contention to feature in this game.''
Josephs, a natural competitior, has won two out of three TKO finals, which all took place in Durban.
He won the first one with Bucs in 2011 when they defeated Bidvest Wits 3-1 at Moses Mabhida, and last season with Bidvest Wits when they edged Bloemfontein Celtic 1-0 at KwaMashu's Princess Magogo Stadium.
He lost a final in 2008 when Pirates went down to Ajax Cape Town 2-1 at Chatsworth Stadium.