Sikhakhane, who is in his second season on loan at Usuthu, will face Pirates in the Telkom Knockout quarter-finals at Moses Mabhida Stadium (18h00).
The Buccaneers have the wind in their sails after beating Kaizer Chiefs in the Soweto Derby last Saturday to stretch their unbeaten streak against their nemesis to 10 games since 2014.
Much is also expected from the Sea Robbers after they finished second on the Absa Premiership log last season.
However, Bucs face an Usuthu side that has yet to lose at home this campaign, although Pirates were the last team to beat them in April at Umlazi's King Zwelithini Stadium.
"Yeah, hey, they are coming and it's a good team," Sikhakhane said.
"I saw then on the weekend [in the Derby] and it's going to be a tough game . We must go there with a positive mind so that we can deal with them and win the game.
"I can assure you that we'll go there with a positive mind. I've got confidence in our players, and we are going to win that game."
Sikhakhane and his teammates will have to be on top of their game at the back to stop the likes of Thembinkosi Lorch, Vincent Pule, Augustine Mulenga and his Zambian compatriot Justin Shonga. The quartet have been a game-changer at the club and proved troublesome for Chiefs at FNB Stadium.
When asked who they should keep an eye on, Sikhakhane, who has been colossal in Usuthu's defence this season, said: "Offensive players are all dangerous, but we are going to manage them.
"One thing I can tell you is we are going to go there and fight. Having also not lost at home, I have taken that off my mind, this is another game now.
"I'm also not saying this because I want to prove a point against them. No, that is not part of me. I won't go there and say, 'Eish, it's my former team and I want to prove them wrong', no. Maybe other players do that, not me."