Ramos, 32, netted the opening strike for Real during their routine 3-0 first-leg victory over Leganes in the last-16 round of the Spanish Cup.
While Brazil wonderkid Vinicius Junior gained all the plaudits, the Spain international skipper reached an iconic moment in his career.
Ramos' headered effort marked his 100th goal for club and country in an illustrious professional career that started at Sevilla back in 2003.
While he only scored three times for his hometown club before his €27m transfer to Los Blancos, the commanding centre-back has developed a reputation as a goalscoring defender.
His 80 goals for the European champions ranks him as 17th highest scorer in the club's history, leaving club legends Guti (77), Luis Figo (56) and Zinedine Zidane (49) in his wake.
Sergio Ramos now has 100 career goals…— Kick Off (@KickOffMagazine) January 10, 2019
He is a defender…???? pic.twitter.com/DLDZ5x9jci