The two sides will do battle in their final fixture of 2017 at the Loftus Versveld Stadium, where kick-off has been scheduled for 19h30.
Top of the log 'Downs will be minus centre-back Motjeka Madisha, while midfielder Sibusiso Masina will be missing for fifth-placed City.
Madisha is set to miss his first game this season after he received his fourth yellow card of the campaign in their 4-1 win over Bloemfontein Celtic over the weekend.
The 22-year-old has been a cog in The Brazilians' defence, having helped his side to seven clean sheets in their 13 outings thus far.
Meanwhile, coach Pitso Mosimane will welcome the return of Tebogo Langerman from suspension, after he missed out their win over Celtic.
The Citizens will also have to do without Masina for the first time since the end of September, when he was cautioned for the fourth time this season in their 1-0 win over AmaZulu.
The 27-year-old has started the last four matches, scoring his first goal of the campaign in their 4-2 defeat to Maritzburg United earlier this month.