Amongst these include Free State Stars and Platinum Stars coaches Luc Eymael and Roger De Sa, who will miss their respective matches against Kaizer Chiefs and Baroka.
Stars will hosts Amakhosi at the Goble Park Stadium while Dikwena will clash with Bakgaga at the Royal Bafokeng Stadium on Wednesday evening – both fixtures are scheduled to kick-off at 19h30.
On Tuesday evening, Bidvest Wits will be without the services of midfield duo Edwin Gyimah and Daylon Claasen when they host Maritzburg United at the Bidvest Stadium (19h30).
The Team of Choice also have Deolin Mekoa and Fortune Makaringe absent from their side for their visit to Johannesburg.
Meanwhile, Chippa United will miss defender Frederick Nsabiyumva for their visit to the Loftus Verveld Stadium, where they take on Mamelodi Sundowns on Wednesday (19h30).
Elsewhere, Sibusiso Sikhosana and Simphiwe Hlongwane will watch on as Polokwane City host SuperSport United, who will be without captain Dean Furman, at the Old Peter Mokaba Stadium (19h30).