Hellings Mhango struck twice to go with strikes from fellow forwards Phakamani Mahlambi and James Keene, and captain Thulani Hlatshwayo.
Rising star Mahlambi opened the scoring in the 20th minute as he snuck a shot under Ajax goalkeeper Jody February.
Defender Hlatshwayo doubled the advantage 11 minutes later against his former club, nodding home a corner by Mogakolodi Ngele.
Malawian forward Mhango made it 3-0 in the 59th minute after pouncing on a mistake from February.
Three minutes later English hitman Keene headed home a Sifiso Hlanti delivery in his first appearance of the season due to injury.
Mhango then completed his brace in the 78th minute for the rampant Clever Boys.
The result leaves Wits on 28 points from 14 matches - level with Cape Town City, but boasting a superior goal difference and two matches in hand.
Kaizer Chiefs are third in the standings with 27 points, while SuperSport United are three points off the pace ahead of their clash with fellow high-flyers Golden Arrows in Tshwane on Wednesday.
Ajax are in 11th spot with 18 points from 16 fixtures.