The Buccaneers host Usuthu at the Orlando Stadium, with kick-off set for 20h15 on Saturday.
Makola and Mobara are currently one booking away from suspension as they have collected three yellow cards apiece.
'Bibo' has picked up cautions in back-to-back games, when Pirates beat Bloemfontein Celtic 1-0 and were held to a 0-0 draw at home by SuperSport United on Tuesday evening.
Meanwhile, Mobara was last booked in the Soweto Derby goalless draw in October, but has only featured twice in his side's six outings since then.
A booking for either of the two this weekend will see them miss out on Pirates' visit to Goble Park, where they are scheduled to face Free State Stars next Saturday (18h00).