The clash was initially scheduled for FNB Stadium on March 2, but Amakhosi have decided to take the Lions of the North on a trip to Durban instead.
The club announced the change on Tuesday after receiving the go-ahead from the PSL.
Venue Change— Kaizer Chiefs (@KaizerChiefs) February 13, 2019
Please note that we will now play Highlands Park at Moses Mabhida Stadium and no longer at FNB Stadium.
The match will be played on Saturday 02 March 2019. Kick off is at 18h00.#AbsaPrem #HailTheChief #Amakhosi4Life pic.twitter.com/j5E0TL9CRm
The exact reason for the change has yet to be confirmed but could be due to their abysmal record in Soweto this season.
The Glamour Boys have yet to register a victory at their traditional home ground since the arrival of Ernst Middendorp while winning just three of their 14 games at the 2010 FIFA World Cup final venue since August.
Before then, however, Chiefs face a trip to Port Elizabeth to face The Magic FC in their Nedbank Cup Last 16 tie this Sunday and then visit Polokwane City at the Peter Mokaba Stadium on February 23.