The Amakhosi assistant coach is set to take charge until the end of the season, before a permanent replacement is announced.
"Following the resignation of head coach Steve Komphela, Kaizer Chiefs have decided that Patrick Mabedi will take charge of the first team for the remainder of the 2017/2018 season," read a statement from the club on Monday.
The 44-year-old former club captain, who lead the side to back-to-back league titles in the 2003/04 and 2004/05 seasons boasts previous head coaching experience with First Division side Cape Town All Stars.
Mabedi was recentl sounded out by the Malawian FA as a part-time assistant coach of the senior national team, but decided against serving his nation in order to focus on his role as second-in-command at Naturena.
He will now have a chance to prove himself in Chiefs' final three games of the season, in which they face Golden Arrows, Maritzburg United and Ajax Cape Town, with former teammate and current reserve team coach Arthur Zwane joining him on the bench.
"Mabedi will be assisted on the bench by Arthur Zwane, who is in charge of Chiefs’ reserve team. Zwane joined Amakhosi in 2000, playing for the first team until 2010," further read the statement.
"In the meantime, the search is on to find a new coach for next season."
The club currently find themselves in fourth position on the log standings – level on points with third-placed Maritzburg – and retain slim hopes of fighting for second position, which is occupied by arch rivals Orlando Pirates at present.