Siyabonga Ngezana, Joseph Molangoane, Willard Katsande and George Maluleka are all currently a yellow card away from being ruled out for one game.
Ngezana and Katsande were both cautioned in Chiefs' 1-0 defeat to Chippa United on Wednesday evening, while Moloagoane and Maluleka escaped Nelson Mandela Bay Stadium without entering into the referee's book.
Amakhosi next face Dikwena at Royal Bafokeng Stadium on Saturday afternoon (15h30), and a booking for either of the quartet could see them miss their outing against Ajax Cape Town in Durban next weekend.
Meanwhile, Steve Komphela will have to make a decision on whether to include Bernard Parker in his travelling squad this weekend, following his facial injury suffered in midweek.
The 31-year-old striker was stretchered off the park in Port Elizabeth and required stitches beneath his eye.