Modise missed his side's previous two games after being forced off with an injury during the 2-0 defeat to Kaizer Chiefs at Cape Town Stadium on September 13.
However, City announced his return to contention on Twitter, saying: 'INJURY UPDATE! Dona is back! #13 Teko Modise is back in training...ready to play his part in this weekend's derby.'
Meanwhile, Ngoma is nearing a return after undergoing knee surgery in July. He scored seven goals and provided 16 assists last term.
"He [Ngoma] is doing very well," club chairman John Comitis tells KickOff.com.
"Yesterday he was on the pitch with the ball, so we are quite excited with his progress.
"In two weeks' time we expect him to be back on the field."