Genk are away at Kortrijk, who have lost four of their last five matches, suggesting it should be an away win.
The South African trio of Siboniso Gaxa, Daylon Claasen and Lance Davids will be hopping to lift Lierse to just their second win of the season as they face fellow strugglers Waregem at home on Saturday.
English Premiership Everton are hopeful that there might be a return for Bafana Bafana playmaker Steven Pienaar, who has missed their last two matches – wins against Birmigham City and Liverpool – with a hamstring injury.
The Toffees are away at Tottenham Hotspur, a club who have long been linked with a move for Pienaar in the January transfer window.
Meanwhile, Benni McCarthy will be hoping for some game-time as his West Ham side host Newcastle, while Kagisho Dikgacoi is nearing fitness, but is unlikely to feature as Fulham travel away to West Brom.
Calvin Kadi and his Portimonense side face giants Benfica in the Portuguese Super Liga on Sunday.
The former Bidvest Wits striker, who is spending the season on loan at Portimonense, has had a good start to his career in Portugal, as despite scoring just one goal, he has been a creative influence for his newly-promoted team and has fast become a fan favourite in Portimão.
Another young South African facing a big test on Sunday is Kamohelo Mokotjo, who has just recently broken into the Feyenoord side in the Dutch Eredivisie.
The team have been struggling this season, winning just two of their nine matches so far and hovering just above the relegation zone.
But one the bright points for them this campaign has been the form of Mokotjo, who has received praise from all and sundry. He faces another test of his ability when the side travels to table-topping PSV Eindhoven for a massive game in their season, one which could spark a revival of fortunes.
Meanwhile in Sweden, midfielder May Mahlangu and his Helsingborgs side need to keep winning as they host relegation-threatened Åtvidabergs.
Helsingborgs are level at the top of the table on 58 points with Malmö, and with just three matches remaining in the season, any slip-ups now could be costly.
Finally, Macbeth Sibaya and his Rubin Kazan side need to win away at CSKA Moscow if they are to have any hope of winning the Russian League for the third year in a row.
Kazan trail leaders Zenit St Petersburg by six points, but ave also played two games more, and have just six matches in which to make up that ground.