The South Americans were on the offensive from the start. Bafana skipper Aaron Mokoena's challenge on Luis Suarez, which appeared dubious, was a sign of bad things to come for Bafana. From the resultant set piece Steven Pienaar became the first player on the night to go into referee Massimo Busacca's book when 'Schillo' charged out early and stopped the shot with his hand, but a retake by Diego Forlan was blocked to safety by Siphiwe Tshabalala.
Suarez was back in the picture in the eighth minute when his shot went wide just to Itumeleng Khune's right, but it was too far off target.
The pressure game finally paid off for Forlan and company in the 24th minute when the former Manchester United striker's shot from on the edge of the box deflected Mokoena giving Khune no chance.
South Africa's half chance fell to Katlego Mphela in the 40th minute. Teko Modise put in a decent cross for ‘Killer', but the latter saw his header go over the bar.
For the better part of the first half Bafana failed to once break the Uruguayan defence and the La Celeste certainly deserved their 1-0 lead going into the break.
Uruguay continued where they left off in the first half. Suarez, the Ajax Amsterdam striker, weaved his way into the box in the 52nd minute and was brought down by Tsepo Masilela, but the referee waved play on, when it could easily have been a penalty. Aware of Uruguay's dominance Bafana coach Carlos Alberto Parreira hauled off Reneilwe Letsholonyane and brought in Surprise Moriri.
However, the surprise was to be provided by the Uruguayans in the 76th minute when Suarez went down under a challenge from Khune and the referee pointed to the spot. The Kaizer Chiefs goalie received marching orders and Pienaar came off to make way for Moeneeb Josephs. Forlan stabbed home from the penalty spot to hand Uruguay a 2-0 lead and some Bafana supporters got off their seats to leave, but they missed the last goal for Uruguay.
In time added on Uruguay put the final nail in the coffin. Forlan played an inch perfect pass to Suarez out wide on the right and Suarez's cross lobbed Josephs for Alvaro Pereira to head into an empty net and 3-0 it finished.