Ramos, 31, made his senior international debut in 2005 at the age of 18, becoming the youngest debutant for La Roja at the time and has since won two UEFA European Championships and the 2010 World Cup.
However, on the eve of reaching another historic milestone as one of the most capped outfield international players, Ramos insists he wants to push further than his former Real Madrid teammate - who retired in 2016.
Casillas reached 167 caps over a 16-year period with the Spanish national team.
"The truth is that it [playing against Germany for 150th cap] is a special moment," he said to reporters, as quoted by Marca. "There is nothing more beautiful than being able to represent my country.
"As long as I maintain that winning spirit, I will continue to represent this team when they call me up.
"I would like to be the player who has worn this shirt the most times, but it won't be easy."