The Blues are at the top of the standings with a nine-point lead over Tottenham, and a further point ahead of City, who are fifth.
However, with 15 games left in the season De Bruyne believes Pep Guardiola's charges still have what it takes to close the gap.
“Football can go a little crazy sometimes,” De Bruyne said, according to Express. “Chelsea are far ahead but even if you lose three games and win three games you can be caught. So three games out of the 15 is nothing.
“We just have to do our thing and not look at what Chelsea and the others are doing. If we win our games we will have a good place and hopefully the best possible chance.
“I don’t know if we can catch them but we are going to try. In the Premier League you have to be there every week.
"All the injured players are coming back, which I am very happy about as we have a lot of games with the league and Champions League. And we will need everyone. It will be very important to have series of wins to put pressure on the rest.”