In what's deemed as the post-Ronaldo era within Spanish media, forward Gareth Bale will look to stamp his authority in this fixture and finally step out the shadow of the club-record scorer.
New head coach Julen Lopetegui has the chance to help Los Blancos become the first side to win three successive Super Cups, in his first competitive game in charge.
Meanwhile, it will be a case in point for Los Rojiblancos, who've significantly strengthened their squad during the transfer window.
"The important thing is the emotion, the hope. This game could be decided on an emotional level," manager Diego Simeone said before the game.
"The arrival of good players guarantees good individuals but not a better team until we are all working in the same direction. Obviously, our budgets are not the same. But in terms of motivation, we never feel beneath anyone.
"In this match, we will do everything."
Real Madrid: Navas, Carvajal, Ramos, Varane, Marcelo, Kroos, Casemiro, Isco, Asensio, Bale, Benzema.
Atletico Madrid: Oblak, Juanfran, Savic, Godín, Lucas Hernández, Koke, Rodri, Saúl, Lemar, Griezmann, Diego Costa.