The West Africans are third in Group E with five points from four games, having claimed their sole win in their previous qualifier against Congo Brazzaville last month.
Kwesi Appiah's side need to beat an improved Uganda - who qualified for this year's AFCON after a 38-year wait - in Kampala and hope pool leaders Egypt (nine points) slip up against the bottom-placed Congolese on Sunday to still be in the race for a spot at Russia 2018.
"It's a very tough game because we're in third position now and we've got five points while Uganda have seven points, and we are playing in Uganda too," Ofori tells KickOff.com.
"So the game is going to be very tough because they drew with us in Ghana. So the second round will be tough. It'll be a great game because they're coming all out to win the game as they have a chance to qualify for the World Cup.
"But I think we have good players, a good team as well. So we need to go there and make ourselves proud and the country proud."
Ghana will be without the influential Ayew brothers as Andre has a knee injury and Jordan is sick.
Ofori admits the pair will be missed.
"Andre is a big player and when you have big players around they'll always motivate and all that stuff," Ofori says.
"But you can't say now that the big players are not around you won't go there and deliver, because now it's about the country. It's about Ghana and we need to go out there and do our best for the nation, for ourselves.
"We need to forget about everything and think about the game and deliver for the nation. Of course they are influential and people know that they're good players in terms of when we attack and when they have the ball they can do something."